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Rheumatic disorders associated with hepatitis C

Identifieur interne : 002489 ( Main/Exploration ); précédent : 002488; suivant : 002490

Rheumatic disorders associated with hepatitis C

Auteurs : Michael Robert Lövy [États-Unis] ; Gordon Starkebaum [États-Unis]

Source :

RBID : ISTEX:093A530ADC97DD32E9FA0DEB1037D0493384A6E3

English descriptors

Abstract

Abstract: The hepatitis C virus (HCV) is a common virus of world-wide distribution affecting up to 3% of the world's population. Its genetic diversity, with multiple subtypes, and existence in the form of quasispecies in individual hosts, is, in part, responsible for high rates of chronic infection. Individuals with HCV infection will undoubtedly present to rheumatologists and other health care professionals with rheumatic and other immunological disorders related to what was usually a remote and asymptomatic acute infection. The goals of this review are: (1) to summarize clinical observations regarding rheumatological and immunological diseases linked with HCV infection; (2) to provide relevant information on the molecular biology of HCV; (3) to discuss the state of the art regarding the use of diagnostic studies; (4) to consider the differential diagnosis of liver disease and rheumatic disorders; and (5) to provide a practical guide to the history, physical examination, laboratory work-up, disease monitoring, and therapy of HCV patients with rheumatic disorders.

Url:
DOI: 10.1053/berh.2000.0092


Affiliations:


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Le document en format XML

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<term>Sjögren's syndrome</term>
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<term>glomerulonephritis</term>
<term>hepatitis C</term>
<term>liver disease</term>
<term>mixed cryoglobulinaemia</term>
<term>neurological manifestations</term>
<term>non-Hodgkin's lymphoma</term>
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<term>skin disorder</term>
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<term>Abdominal pain</term>
<term>Abnormal lbts</term>
<term>Abnormal objective tests</term>
<term>Abnormality</term>
<term>Active hepatitis</term>
<term>Active liver disease</term>
<term>Acute hepatitis</term>
<term>American journal</term>
<term>Anticardiolipin antibody</term>
<term>Appropriate patients</term>
<term>Arthralgia</term>
<term>Arthritis</term>
<term>Autoantibody</term>
<term>Autoimmune</term>
<term>Autoimmune disease</term>
<term>Autoimmune disorders</term>
<term>Autoimmune hepatitis</term>
<term>Autoimmune syndromes</term>
<term>Autoimmune thrombocytopenia</term>
<term>Biopsy</term>
<term>British journal</term>
<term>Cell expansions</term>
<term>Cell lymphoproliferative disorders</term>
<term>Chronic hepatitis</term>
<term>Chronic infection</term>
<term>Chronic liver disease</term>
<term>Cirrhosis</term>
<term>Clinical course</term>
<term>Clinical manifestations</term>
<term>Clinical observations</term>
<term>Clinical rheumatology</term>
<term>Clonal</term>
<term>Clonal expansions</term>
<term>Common skin problems</term>
<term>Complement components</term>
<term>Complete evaluation</term>
<term>Core protein</term>
<term>Cryoglobulinaemia</term>
<term>Cryoglobulinaemia type</term>
<term>Cryoglobulinemia</term>
<term>Cryoglobulins</term>
<term>Cutanea</term>
<term>Cutaneous</term>
<term>Cutaneous polyarteritis nodosa</term>
<term>Cutaneous vasculitis</term>
<term>Cytoplasmic</term>
<term>Diagnostic studies</term>
<term>Diagnostic tests</term>
<term>Disorder</term>
<term>Enzyme immunoassay</term>
<term>Experimental rheumatology</term>
<term>Extrahepatic</term>
<term>Extrahepatic complications</term>
<term>Extrahepatic manifestations</term>
<term>Fulminant hepatitis</term>
<term>Gastroenterology</term>
<term>Genetic diversity</term>
<term>Genome</term>
<term>Genotype</term>
<term>Geographical location</term>
<term>Glomerulonephritis</term>
<term>Haematopoietic progenitor cells</term>
<term>Healthy carrier state</term>
<term>Hematopoietic cells</term>
<term>Hepatitis</term>
<term>Hepatocellular carcinoma</term>
<term>Hepatology</term>
<term>High prevalence</term>
<term>High rates</term>
<term>Histological</term>
<term>Histological changes</term>
<term>Histological evidence</term>
<term>Immune</term>
<term>Immune complexes</term>
<term>Immunoglobulin</term>
<term>Immunoglobulin genes</term>
<term>Immunological disorders</term>
<term>Immunosuppressive drugs</term>
<term>Infection</term>
<term>Initial treatment</term>
<term>Interferon therapy</term>
<term>Internal medicine</term>
<term>International journal</term>
<term>Knoedell score</term>
<term>Laboratory disease monitoring</term>
<term>Large groups</term>
<term>Lesion</term>
<term>Leukocytoclastic vasculitis</term>
<term>Lichen</term>
<term>Lichen planus</term>
<term>Liver abnormalities</term>
<term>Liver biopsy</term>
<term>Liver disease</term>
<term>Lovy</term>
<term>Lymphocytic sialadenitis</term>
<term>Lymphoma</term>
<term>Lymphoproliferative</term>
<term>Lymphoproliferative diseases</term>
<term>Malignant lymphoproliferative disorders</term>
<term>Malignant transformation</term>
<term>Manifestation</term>
<term>Many patients</term>
<term>Membranoproliferative glomerulonephritis</term>
<term>Membranous</term>
<term>Membranous glomerulonephritis</term>
<term>Microscopic polyangiitis</term>
<term>Mild arthritis</term>
<term>Mild liver disease</term>
<term>Mild synovitis</term>
<term>Molecular biology</term>
<term>Monoclonal</term>
<term>Monoclonal expansions</term>
<term>Monoclonal gammopathies</term>
<term>Mononeuritis multiplex</term>
<term>Multivirc group</term>
<term>Ndings</term>
<term>Necrolytic acral erythema</term>
<term>Necrolytic erythema</term>
<term>Nephrotic syndrome</term>
<term>Neurological manifestations</term>
<term>Neuropathy</term>
<term>Nodosa</term>
<term>Normal lbts</term>
<term>Normal liver function</term>
<term>Objective tests</term>
<term>Ocular disease</term>
<term>Oral lichen planus</term>
<term>Other aetiologies</term>
<term>Other forms</term>
<term>Other hand</term>
<term>Palpable purpura</term>
<term>Pathological changes</term>
<term>Peripheral neuropathy</term>
<term>Physical examination</term>
<term>Planus</term>
<term>Plasma exchange</term>
<term>Plausible mechanism</term>
<term>Polyarteritis</term>
<term>Polyarteritis nodosa</term>
<term>Porphyria</term>
<term>Porphyria cutanea tarda</term>
<term>Positive patients</term>
<term>Potential hepatotoxicity</term>
<term>Practical guide</term>
<term>Present illness</term>
<term>Prevalence</term>
<term>Primary syndrome</term>
<term>Recent review</term>
<term>Recent studies</term>
<term>Relative contraindications</term>
<term>Relevant information</term>
<term>Renal</term>
<term>Rheumatic</term>
<term>Rheumatic diseases</term>
<term>Rheumatic disorders</term>
<term>Rheumatic manifestations</term>
<term>Rheumatic symptoms</term>
<term>Rheumatoid</term>
<term>Rheumatoid arthritis</term>
<term>Rheumatoid factor</term>
<term>Rheumatology</term>
<term>Risk factor</term>
<term>Risk factors</term>
<term>Salivary</term>
<term>Salivary gland biopsies</term>
<term>Salivary gland biopsy</term>
<term>Serological</term>
<term>Serological abnormalities</term>
<term>Sicca symptoms</term>
<term>Sicca syndrome</term>
<term>Starkebaum</term>
<term>Starkebaum table</term>
<term>Subcutaneous nodules</term>
<term>Substantial evidence</term>
<term>Such patients</term>
<term>Syndrome</term>
<term>Tarda</term>
<term>Thrombocytopenia</term>
<term>Transaminase levels</term>
<term>Ursodeoxycholic acid</term>
<term>Vasculitis</term>
<term>Vessel walls</term>
<term>Viral</term>
<term>Viral hepatitis</term>
<term>Viral replication</term>
<term>Virus</term>
<term>Virus infection</term>
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<div type="abstract" xml:lang="en">Abstract: The hepatitis C virus (HCV) is a common virus of world-wide distribution affecting up to 3% of the world's population. Its genetic diversity, with multiple subtypes, and existence in the form of quasispecies in individual hosts, is, in part, responsible for high rates of chronic infection. Individuals with HCV infection will undoubtedly present to rheumatologists and other health care professionals with rheumatic and other immunological disorders related to what was usually a remote and asymptomatic acute infection. The goals of this review are: (1) to summarize clinical observations regarding rheumatological and immunological diseases linked with HCV infection; (2) to provide relevant information on the molecular biology of HCV; (3) to discuss the state of the art regarding the use of diagnostic studies; (4) to consider the differential diagnosis of liver disease and rheumatic disorders; and (5) to provide a practical guide to the history, physical examination, laboratory work-up, disease monitoring, and therapy of HCV patients with rheumatic disorders.</div>
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